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What is AIH?

Autoimmune hepatitis (AIH) is a chronic disease that occurs when patients’ immune systems attack their livers and sometimes damage them. With treatment, most patients don’t need liver transplants and have normal life expectancies.

Autoimmune hepatitis (AIH) is a chronic disease that is treated long-term, often for life. There is no cure for AIH, but the disease can be controlled through medication. It is not contagious.

Causes.

AIH is caused by an overactive immune system that attacks normal liver cells because it mistakes them for foreign agents such as viruses or bacteria. It's a rare autoimmune liver disease that affects all ages and ethnicities; however, it affects men and women disproportionately.

Unknown contributors to autoimmune hepatitis.

Learn more about the causes of autoimmune hepatitis.

Symptoms.

​The initial and long-term symptoms associated with autoimmune hepatitis are commonly different among patients. There is a wide spectrum of complaints in patients with AIH. It remains unclear why these symptoms are present in some and not in others.​

Common reported symptoms such as fatigue, nausea, and difficulty sleeping.

difficulty sleeping

fatigue

itchy skin

loss of appetite

abdominal discomfort, including pain in the right upper quadrant.

joint pain

nausea

jaundice

dry mouth or eyes

skin rashes

anxiety & depression

Diagnosis.

A gastroenterologist or hepatologist typically diagnoses a patient with AIH based on a patient’s symptoms, a physical examination, blood tests, and a liver biopsy. Your primary care doctor may be the first to see you because of symptoms or abnormal liver tests.

A stethoscope.
A medical practitioner.

Before a diagnosis of AIH is made, a hepatologist or gastroenterologist will rule out other causes of liver injury and may ask questions about alcohol and drug use including prescribed medications, vitamins, supplements, and recreational drugs to determine if these could have contributed to liver injury.  

Learn more about an autoimmune hepatitis diagnosis.

Treatments.

Pills and pill bottle.

Immunosuppressants decrease liver inflammation and help prevent additional liver damage by guarding against further destruction of liver cells. Once medication for AIH is started, liver tests typically return to normal within a few months. 

 
 
 
 
 

Overview.